Tanning injections come in two forms: melanotan I and melanotan II. Both types of injections work by replicating alpha-melanocyte-stimulating hormone in your body. This hormone binds to melanocortin receptors and stimulates the production of the pigment melanin in your skin cells. The more melanin your skin cells produce, the darker your skin appears.
Melanotan II binds with a wider range of receptors than melanotan I and has a shorter life in your body. It can also cross your blood-brain barrier, which can cause side effects like appetite loss, sexual dysfunction, and fatigue. Melanotan II is not currently used to treat any medical conditions.
In one observational survey, researchers questioned 21 volunteers who had used melanotan in the past, were actively using it at the time of the survey, or were considering using it in the future. The researchers found that the most common side effects were:
More research needs to be done before scientists can confirm whether melanotan increases your risk of developing skin cancer. Still, this remains one of the biggest concerns around the use of tanning injections.
In one of the case studies, a 20-year-old woman was referred to a dermatology clinic after developing a jet-black mark over her glute that was later diagnosed as melanoma. She had been injecting melanotan II every other day for 3 to 4 weeks.
According to a 2020 review, melanotan II has been linked to a potentially life threatening condition called renal infarction. Renal infarction develops when blood flow to your kidneys is blocked. It has a mortality rate of about 11.4 percent within the first month of diagnosis.
It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.
Unlicensed, untested, or fraudulent products sold as \"melanotan II\" are found on the Internet, and purported to be effective as \"tanning drugs\", though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.
In the synthesis of melanotan II, an ε-amino group of lysine and an γ-carboxy group of aspartic acid have their orthogonal protection removed before undergoing a carbodiimide mediated lactamization, leading to an intermediate. This intermediate, when attached to N-acetylnorleucine, forms melanotan II. The entire process can be accomplished in 12 steps with an overall yield of 2.6%, and the product is more than 90% pure without preparative chromatography.
Research in the early 1960s showed that in rats, administration of α-MSH caused sexual arousal, and work on this continued in many labs up through the 1980s, when scientists at the University of Arizona began attempting to develop α-MSH and analogs as potential sunless tanning agents, and synthesized and tested several analogs, including melanotan-I and melanotan II.
Early in the research process one of the scientists, who was conducting experiments on himself with an early tool compound, melanotan II, injected himself with twice the dose he intended to and got an eight-hour erection, along with nausea and vomiting.
As a tanning agent, melanotan I (now known as afamelanotide) was licensed by Competitive Technologies, a technology transfer company operating on behalf of the University of Arizona, to an Australian startup called Epitan, which changed its name to Clinuvel in 2006.
As a sexual dysfunction agent, melanotan II was licensed by Competitive Technologies to Palatin Technologies. Palatin ceased development of melanotan II in 2000 and synthesized, patented, and began to develop bremelanotide, a likely metabolite of melanotan II that differs in that it has a hydroxyl group where melanotan II has an amide. Competitive Technologies sued Palatin for breach of contract and tried to claim ownership of bremelanotide; the parties settled in 2008 with Palatin retaining rights to bremelanotide, returning rights to melanotan II to Competitive Technologies, and paying US$800,000.
The Therapeutic Goods Administration last month warned about the use of products containing melanotan, a prescription-only medicine used to support the management of a rare, incurable genetic disease, which is being misused by some people to darken their skin.
While melanotan I has been approved in Australia for highly specialised use, melanotan II has never been assessed by the TGA and its development as a potential medicine was stopped years ago due to safety reasons.
Skerritt said there had been an increase in posts promoting the misuse of drugs on social media platforms. He also said the regulator was looking at acting against companies selling melanotan via links from social media posts.
The Therapeutic Goods Administration last month about the use of products containing melanotan, a prescription-only medicine used to support the management of a rare, incurable genetic disease, which is being misused by some people to darken their skin.
Another video shows a young man saying he had experienced side effects from using melanotan and felt \\\\u201Clike absolute dog s---, but it\\\\u2019s worth it\\\\u201D. \\\\u201CDo your own research,\\\\u201D he said. \\\\u201CIt\\\\u2019s got its negatives. I love this s---.\\\\u201D
Former LA-based celebrity facialist Ingrid Seaburn said she had warned \\\\u201Ccurious\\\\u201D clients of her Bondi-based skin health studio about the risks of melanotan, pointing out \\\\u201Cthe only safe tan was a fake tan\\\\u201D.
Some social media influencers have recently been promoting tanning products containing melanotan II, an illegal artificial hormone that can accelerate tanning. These products come in the form of injections and nasal sprays.
While Prof. Cass and his colleagues expected to find around 10 ingredients in a licensed medication, they were shocked to discover that some of the products analyzed contained over 100 unidentified ingredients, alongside melanotan II.
Melanotan II is an unlicensed and largely untested form of alpha-melanocyte-stimulating hormone, which causes pigmentation (tanning) of human skin. Melanotan II is a variant of melanotan I (afamelanotide), a drug used in the treatment of erythropoietic protoporphyria.
Melanotan II non-selectively mimics the action of melanocortin peptides. These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like melanotan I (afamelanotide), melanotan II stimulates the production of eumelanin, causing the skin to go darker (tanning).
During clinic trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. A new drug based on melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.
Reconstituted with bacteriostatic water, Melanotan 2 research peptide remains potent and preserved. Reconstituting Melanotan 2 peptide is a necessity and will require proper due diligence for results. Nasal sprays, pre-mixed Melanotan 2, pills, oral melanotan2 are not legitimate. Enzymes will render the peptide inactive if ingested. Purchase only pure Melanotan II custom synthesis.
Melanotan Shipping: Melanotan peptides are durable and stable. Shipping in the summer not a problem for tanning melanocortins. When receiving MT-2 it is recommended to store in the refrigerator. Save money and do not pay for cold melanotan 2 shipments. Further, do not store Melanotan 2 in freezer.
UV Radiation: Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is necessary to develop a tan for most folks. Without it, almost nothing happens. In other words, NO UV = NO TAN. Melanotan use for a full month and with UV exposure, you (and your friends) will be astounded by how fast and how dark MT-II tanning results. Areas of skin that are typically sun-exposed in your day to day life will respond more readily to the effects of the melanotan peptides, take photo therapy serious with Melanotan II.
Do you have to inject Melanotan PeptidesYes. The best, most efficient method of administering Melanotan peptides are subcutaneous (subq) injection. Nasal sprays are inconsistent and inefficient at best. No detectable levels were observed following oral melanotan dosing.
Melanotan Dosage: Knowing your skin type is one detail which will help create a public user log. There are thousands of melanotan users worldwide who share the experience. Raise awareness and help others who want to hear success stories, complications and failures. 59ce067264